I'm a Bioinformatics Scientist at [Illumina](http://www.illumina.com/), based at their R&D site near Cambridge, UK. Here I develop software and use data science, machine learning and statistical programming to analyse large volumes of high-throughput sequencing data.
## Employment
`2015-`
__Illumina, Inc.__ Bioinformatics scientist (data scientist and statistical programmer)
## Education
`2012-15`
__University of Edinburgh__ Bioinformatics PhD (supervisors: Colin Semple and Stuart Aitken). My thesis was titled _Unravelling higher order chromatin organisation through statistical analysis_ and is available through the [Edinburgh Research Archive](https://www.era.lib.ed.ac.uk/handle/1842/22906).
`2011-12`
__Imperial College London__ MSc Bioinformatics and Theoretical Systems Biology (_Distinction_)
`2008-11`
__University of York__ BSc Biology (_First class honours_)
## Presentations
### Tutorials
`2014`
WikiProject Computational Biology half-day tutorial (_ISMB_, Boston, USA)
### Talks
`2015`
EdinbR: The Edinburgh R usergroup (_various_)
MRC IGMM research seminars and section meetings (_various_)
blogR: pop data analysis and R for the web (_Psychology R-users_, Edinburgh, UK)
### Posters
`2015`
_Keystone Epigenomics_ (Keystone CO, USA)
`2014`
_ISMB_ (Boston MA, USA)
_Genome informatics_ (Cambridge, UK)
_Chromatin: From nucleosomes to chromosomes_ (Cambridge, UK)
`2013`
_Genome informatics_ (CSHL NY, USA)
_EpiGeneSys_ (Cambridge, UK)
## Publications
<!-- ### Journals -->
`2017`
Peluso S, Douglas A, Hill A, De Angelis C, __Moore BL__ _et al._ Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors. _eLife_, 6: e28590.
Eberle MA, Fritzilas E, Krusche P, Källberg M, __Moore BL__ _et al._ A reference data set of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree. _Genome Research_, 27:157-164.
`2016`
Yu N, Nützmann H-W, MacDonald JT, __Moore B__ _et al._ Delineation of metabolic gene clusters in plant genomes by chromatin signatures. _Nucleic Acids Research_, 44(5):2255-2265.
`2015`
__Moore BL__ _et al._ Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization. _Genome Biology_, 16:110.
Fraser J, Ferrai C, Chiariello AM, Schueler M, Rito T, Laudanno G, Barbieri M, __Moore BL__ _et al._ Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation. _Molecular systems biology_, 11:852.
`2013`
__Moore BL__ _et al._ High–quality protein backbone reconstruction from alpha carbons using Gaussian mixture models. _Journal of computational chemisty_, 34(22):1881-9.
`2014` Pieces in _The Huffington Post_ (US): Here Are the Most Overrated and Underrated Movies of All Time; Celebrity Twitter Followers, by Gender ([huffingtonpost.com/benjamin-moore](http://www.huffingtonpost.com/benjamin-moore/))
`2006–` Articles for _English Wikipedia_: European Nucleotide Archive, RNA thermometer, Toxin-antitoxin system and more ([en.wikipedia.org/wiki/User:Ben_Moore](https://en.wikipedia.org/wiki/User:Ben_Moore)).
## Technical skills
* R
* Python
* Javascript (incl. Typescript, Angular)
* Go
* HTML and CSS
* LaTeX
* Bash
* Git / Mercurial
* UNIX
* Cluster computing
* Docker
* AWS
## Areas of expertise
* Bioinformatics
* Statistics
* Machine learning
* Data visualisation
* Software development
* NGS and variant calling
## Projects
### github
My [personal github account](https://github.com/blmoore) hosts my hobby development projects as well as listing contributions to open source tools. Examples include: shiny apps [blackspot](https://github.com/blmoore/blackspot) and [shinybrot](https://github.com/blmoore/shinybrot), as well as an R package hosted by CRAN ([mandelbrot](https://github.com/blmoore/mandelbrot)).
### blog
I write a data science blog at [blm.io](http://blm.io/blog) where I apply R and Python to open datasets and write-up the results. My posts have been featured by sites including FiveThirtyEight, BuzzFeed, AVclub, io9 and more, and also led to being an invited blogger at the Huffington Post. My original wordpress blog ([benjaminlmoore.wordpress.com](http://benjaminlmoore.wordpress.com)) has received over 150,000 unique visitors from 180 countries.
### EdinbR
I co-founded a usergroup for the R programming language in Edinburgh called EdinbR. I helped to organise our monthly meetings and built our website: [edinbr.org](http://edinbr.org). Our meetings attract 30-50 statisticians, data scientists and developers for talks and discussion about the R language and its applications. We're sponsored by Revolution Analytics and have an organisational github account at [github.com/EdinbR](https://github.com/EdinbR).
### datarea
I entered Imperial College's [Summer Data Challenge](https://www.imperial.ac.uk/data-science/education/summer-data-challenge/) competition, where entrants analysed a given dataset and then proposed a startup idea based on their results. I developed a modelling technique to select housing areas for investment and was awarded third place: £2,000 and startup support from Imperial Create Lab. My entry can be seen at [blm.io/datarea](http://blm.io/datarea) and the code is shared on my github account.
## Awards
MRC Capacity building scholarship (PhD fees + enhanced stipend)
MRC Full postgraduate scholarship (MSc fees + stipend)
ISCB computational biology Wikipedia competition 2013 ([doi:10.1371/journal.pcbi.1003242](http://dx.doi.org/10.1371/journal.pcbi.1003242); 2nd place)
Imperial Create Lab's "Summer data challenge" ([summerdatachallenge.com](http://summerdatachallenge.com); 3rd place)
Individual engagement grant from the Wikimedia Foundation to attend ISMB 2014
Training accreditation for Wikimedia UK, the national chapter of the Wikimedia Foundation
Front cover design selected for J. Comp. Chem. (34:22) ([doi:10.1002/jcc.23388](http://dx.doi.org/10.1002/jcc.23388))
